The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo. Deleting a single ...
Deleting a single amino acid (Pro230) in the lower hinge produced half-IgG1 molecules with disrupted disulfide bonds and reoriented Fab and Fc regions, highlighting the hinge’s essential role in ...
13d
NMR reveals site-specific structural signatures of therapeutic antibodies without isotope labeling
Monoclonal antibodies are widely used to treat diseases ranging from cancer to autoimmune disorders. The safety and efficacy ...
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