Did you know excessive sleepiness might signal brain issues? 🧠 Orexin neurons play a crucial role in sleep cycles! 🌙 Talk to your doctor about orexin dysfunction! 💬 #SleepHealth #CognitiveFunction #Orexin #DrLewisClarke #BrainHealth #SleepDisorders #PAMHealth | Lewis K. Clarke MD, PhD
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Did you know excessive sleepiness might signal brain issues? 🧠 Orexi…
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Ishikawa et al. show that an orexin receptor 2 (OX2R) agonist improves the maintenance of wakefulness through OX2R in the tuberomammillary nucleus (TMN) and basal forebrain (BF) regions and suppresses cataplexy through OX2R in the ventrolateral periaqueductal gray and lateral pontine tegmentum (vlPAG/LPT) regions.📹 Video abstract © Ishikawa et al. To find out more check out this open access article linked in our bio and here: https://www.cell.com/current-biology/fulltext/S0960-9822(25)00356-2 |
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Patients with narcolepsy type 1 have severely low or absent levels of brain orexin neuropeptides. TAK-994 is an oral orexin receptor 2 agonist under study for the treatment of narcolepsy type 1. New research findings are summarized in this short video. https://nej.md/44EI1EB | The New England Journal of Medicine
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